Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats

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Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats

The high rate of male infertility and the meager resources to manage same in sub Saharan Africa have necessitated the search for cost effective and available alternatives. Mushrooms have been used traditionally in folk medicine and as nutraceuticals. This study has investigated the effect of the wild mushroom Pleurotus tuber-regium on carbon tetrachloride (CCl4) deleterious effects on the repro...

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Carbon tetrachloride induced hepatorenal toxicity in rats: possible protective effects of wild Pleurotus tuber-regium

Background: The economic cost of and liver and kidney diseases in Sub Saharan Africa remain prohibitive, hence the quest for medicinal foods that can reverse hepato-renal damages. The aim of this study is to investigate the hepato-renal protective effect of wild edible P.tuber-regium on carbon tetrachloride (CCl4) induced oxidative stress in male Sprague–Dawley rats. Method: Thirty six rats wer...

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Protective Effects of Hydro-alcoholic Extract of Apium Graveolens on Carbon Tetrachloride Induced Hepatotoxicity in Sprague-Dawley male Rats

  Background & Objective: Apium graveolens has antioxidant property because of its flavonoid compounds. In the present study, we investigated the hepatoprotective effects of hydroalcoholic extract of Apium graveolens in Sprague Dawley male rats treated with carbon tetrachloride (CCl4). Materials & Methods: In this study, 48 rats (weighted 180-200 gram) were divided into six groups each having e...

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Pleurotus tuber-regium mushrooms in the diet of rats ameliorates reproductive and testicular injury caused by carbon tetrachloride

Background: The incidence of male infertility arising from male sexual dysfunction is high especially in the sub saharan Africa. African foods may hold promise to reverse this trend. The aim of this study therefore is to evaluate the improvement of the reproductive and testicular injuries mediated by CCl4 by the use of a wild edible mushroom, P. tuber-regium. Methods: Sixty rats were divide int...

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Prophylactic effects of thymoquinone against carbon tetrachloride- induced hepatic damage in Sprague-Dawley rats

Article history: Received on: 09/12/2015 Revised on: 27/12/2015 Accepted on: 12/01/2016 Available online: 27/02/2016 This study is conducted to investigate the prophylactic effect of thymoquinone (TQ), the major active ingredient of Nigella sativa seeds, against carbon tetrachloride (CCl4)-induced hepatic damage in Sprague-Dawley (SD) rats. Forty rats were divided into four even groups. The fir...

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ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2016

ISSN: 1663-9812

DOI: 10.3389/fphar.2016.00480